Tolibut
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| Clinical data | |
|---|---|
| ATC code | None |
| Identifiers | |
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| CAS Number |
28311-38-8 28311-37-7 (HCl) |
| PubChem (CID) | 49344 |
| ChemSpider | 44852 |
| Chemical and physical data | |
| Formula | C11H15NO2 |
| Molar mass | 193.2423 g/mol |
| 3D model (Jmol) | Interactive image |
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Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substition. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia, though it may have been.[1][2][3][4] Tolibut probably acts as a GABAB receptor agonist similarly to phenibut and baclofen.
References
- ↑ Tyurenkov, I. N.; Borodkina, L. E.; Bagmetova, V. V. (2012). "Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock". Bulletin of Experimental Biology and Medicine. 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. ISSN 0007-4888.
- ↑ I. S. Morozov, G. I. Kovalev, N. I. Maisov, G. V. Kovalev, K. S. Raevskii (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". 11 (1): 10–12. doi:10.1007/BF00779108.
- ↑ Dmitriev AV, Andreev NIu (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakol Toksikol (in Russian). 50 (1): 24–7. PMID 3556547.
- ↑ Artem'ev IIu, Darinskiĭ IuA, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksp Klin Farmakol (in Russian). 55 (1): 16–8. PMID 1363942.
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