Canbisol
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| Clinical data | |
|---|---|
| ATC code | none |
| Identifiers | |
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| CAS Number |
56689-43-1  |
| PubChem (CID) | 41969 |
| ChemSpider |
16736847  |
| UNII |
NZ1ZPC4WSF |
| ChEMBL |
CHEMBL2105525 |
| Chemical and physical data | |
| Formula | C24H38O3 |
| Molar mass | 374.555 g/mol |
| 3D model (Jmol) | Interactive image |
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| (what is this?) (verify) | |
Canbisol (Nabidrox), is a synthetic cannabinoid derivative that is the dimethylheptyl homologue of 9-nor-9β-hydroxyhexahydrocannabinol (HHC). It is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.1nM at CB1 and 0.2nM at CB2.[1] It is mainly used in scientific research, in receptor binding studies to determine the structure and function of the cannabinoid receptors,[2][3][4] but has been made illegal in some countries due to its possible abuse potential as a cannabinomimetic drug.[5]
See also
References
- ↑ Rhee MH; et al. (September 1997). "Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase". Journal of Medicinal Chemistry. 40 (20): 3228–33. doi:10.1021/jm970126f. PMID 9379442.
- ↑ Rhee MH; et al. (December 2000). "Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor". Journal of Neurochemistry. 75 (6): 2485–91. doi:10.1046/j.1471-4159.2000.0752485.x. PMID 11080201.
- ↑ Rhee MH (September 2002). "Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor". Journal of Veterinary Science. 3 (3): 185–91. PMID 12514330.
- ↑ Zhang R; et al. (July 2005). "Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template". Molecular Pharmacology. 68 (1): 69–83. doi:10.1124/mol.104.007823. PMID 15840841.
- ↑ The Misuse of Drugs Act 1971 (Amendment) Order 2009
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