PF-3845
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| Clinical data | |
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| ATC code | None |
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| Identifiers | |
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| CAS Number | 1196109-52-0 |
| PubChem (CID) | 25154867 |
| Chemical and physical data | |
| Formula | C24H23F3N4O2 |
| Molar mass | 456.459 g/mol |
| 3D model (Jmol) | Interactive image |
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PF-3845 is a selective inhibitor of fatty acid amide hydrolase.[1] It results in increased levels of anandamide and results in cannabinoid receptor-based effects. It has anti-inflammatory action in mice colitis models. Antidiarrheal and antinociceptive effects were also seen in mouse models of pain.[2]
References
- ↑ Ahn, K; Johnson, DS; Mileni, M; Beidler, D; Long, JZ; McKinney, MK; Weerapana, E; Sadagopan, N; Liimatta, M; Smith, SE; Lazerwith, S; Stiff, C; Kamtekar, S; Bhattacharya, K; Zhang, Y; Swaney, S; Van Becelaere, K; Stevens, RC; Cravatt, BF (24 April 2009). "Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.". Chemistry & Biology. 16 (4): 411–20. doi:10.1016/j.chembiol.2009.02.013. PMID 19389627.
- ↑ Fichna, J.; Sałaga, M.; Stuart, J.; Saur, D.; Sobczak, M.; Zatorski, H.; Timmermans, J.-P.; Bradshaw, H. B.; Ahn, K. (2014-04-01). "Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides". Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society. 26 (4): 470–481. doi:10.1111/nmo.12272. ISSN 1365-2982. PMID 24460851.
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