Eicosanoid receptor
An eicosanoid receptor is an integral membrane protein that detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.[1]
The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:[2][3]
Leukotriene
- BLT1 (Leukotriene B4 receptor) - LTB4R
- BLT2 (Leukotriene B4 receptor 2) -
- CysLT1 (Cysteinyl leukotriene receptor 1) - CYSLTR1
- CysLT2 (Cysteinyl leukotriene receptor 2) - CYSLTR2
- GPR99/OXGR1 - GPR99, may constitute a third CysLTR.[4]
- GPR17 - GPR17, may constitute the fourth receptor for cysteinyl leukotrienes.[5][6]
Lipoxin
- LXA4R (Formyl peptide receptor-like 1) - FPRL1
Oxoeicosanoid
Prostanoid
- PGD2: DP-(PGD2) (PGD2 receptor)
- PGE2: EP-(PGE2) (PGE2 receptor)
- PGF2α: FP-(PGF2α) (PTGFR) - PTGFR
- PGI2 (prostacyclin): IP-(PGI2) (PTGIR) - PTGIR
- TXA2 (thromboxane): TP-(TXA2) (TBXA2R) - TBXA2R
References
- ↑ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). "The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers". Carcinogenesis. 19 (1): 49–53. doi:10.1093/carcin/19.1.49. PMID 9472692.
- ↑ Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
- ↑ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). "International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors". Pharmacol. Rev. 55 (1): 195–227. doi:10.1124/pr.55.1.8. PMID 12615958.
- ↑ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866
. PMID 23504326. - ↑ Fumagalli M, Lecca D, Abbracchio MP (2016). "CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17". Neuropharmacology. 104: 82–93. doi:10.1016/j.neuropharm.2015.10.005. PMID 26453964.
- ↑ Burnstock G (2016). "An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration". Neuropharmacology. 104: 4–17. doi:10.1016/j.neuropharm.2015.05.031. PMID 26056033.
- ↑ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665.
External links
- "Leukotriene Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- "Prostanoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Eicosanoid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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