Ulp1 peptidase

Ulp1 peptidase
Identifiers
EC number 3.4.22.68
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Ulp1 peptidase (EC 3.4.22.68, Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-!Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3

The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human.

References

  1. Lima, C.D.; Rawlings, N.D.; Woessner, J.F. (2004). "Ulp1 endopeptidase". In Barrett, A.J. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1340–1344.
  2. Li, S.-J.; Hochstrasser, M. (1999). "A new protease required for cell-cycle progression in yeast". Nature. 398 (6724): 246–251. doi:10.1038/18457. PMID 10094048.
  3. Taylor, D.L.; Ho, J.C.; Oliver, A.; Watts, F.Z. (2002). "Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease". J. Cell Sci. 115 (Pt 6): 1113–1122. PMID 11884512.
  4. Li, S.-J.; Hochstrasser, M. (2003). "The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity". J. Cell Biol. 160 (7): 1069–1081. doi:10.1083/jcb.200212052. PMID 12654900.
  5. Ihara, M.; Koyama, H.; Uchimura, Y.; Saitoh, H.; Kikuchi, A. (2007). "Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth". J. Biol. Chem. 282: 16465–16475. doi:10.1074/jbc.M610723200. PMID 17428805.
  6. Mukhopadhyay, D.; Dasso, M. (2007). "Modification in reverse: the SUMO proteases". Trends Biochem. Sci. 32 (6): 286–295. doi:10.1016/j.tibs.2007.05.002. PMID 17499995.
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