CAPN5

CAPN5
Identifiers
Aliases CAPN5, ADNIV, HTRA3, VRNI, nCL-3, calpain 5
External IDs MGI: 1100859 HomoloGene: 31212 GeneCards: CAPN5
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

726

12337

Ensembl

ENSG00000149260

ENSMUSG00000035547

UniProt

O15484

O08688

RefSeq (mRNA)

NM_004055

NM_001301250
NM_007602

RefSeq (protein)

NP_004046.2

NP_001288179.1
NP_031628.1

Location (UCSC) Chr 11: 77.07 – 77.13 Mb Chr 7: 98.12 – 98.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.[3][4][5]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024.
  4. Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857.
  5. 1 2 "Entrez Gene: CAPN5 calpain 5".

Further reading

External links


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