Mothers against decapentaplegic homolog 5

SMAD5
Identifiers
Aliases	SMAD5, DWFC, JV5-1, MADH5, SMAD family member 5
External IDs	OMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: SMAD5
Gene ontology Molecular function • DNA binding • signal transducer activity, downstream of receptor • transcription factor activity, sequence-specific DNA binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • metal ion binding • protein binding • ubiquitin protein ligase binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • cytoplasm • integral component of membrane • SMAD protein complex • cytosol • transcription factor complex • intracellular • nucleoplasm • protein complex • nucleus Biological process • germ cell development • ureteric bud development • cardiac muscle contraction • regulation of transcription, DNA-templated • SMAD protein signal transduction • embryonic pattern specification • ossification • cellular response to organic cyclic compound • cellular response to BMP stimulus • BMP signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • Mullerian duct regression • protein phosphorylation • cartilage development • positive regulation of osteoblast differentiation • erythrocyte differentiation • bone development • transforming growth factor beta receptor signaling pathway • signal transduction • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • positive regulation of transcription from RNA polymerase II promoter • osteoblast fate commitment Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4090	17129
Ensembl	ENSG00000113658	ENSMUSG00000021540
UniProt	Q99717	P97454
RefSeq (mRNA)	NM_005903 NM_001001419 NM_001001420	NM_001164041 NM_001164042 NM_008541
RefSeq (protein)	NP_001001419.1 NP_001001420.1 NP_005894.3	NP_001157513.1 NP_001157514.1 NP_032567.1
Location (UCSC)	Chr 5: 136.13 – 136.19 Mb	Chr 13: 56.7 – 56.74 Mb
PubMed search	[1]	[2]
Wikidata

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.^[3]

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.^[4] It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

References