YY1

YY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UBD, 1ZNM, 4C5I
Identifiers
Aliases	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor
External IDs	MGI: 99150 HomoloGene: 2556 GeneCards: YY1
Gene ontology Molecular function • DNA binding • transcription corepressor activity • transcription coactivator activity • zinc ion binding • metal ion binding • protein binding • four-way junction DNA binding • enhancer sequence-specific DNA binding • RNA binding • nucleic acid binding • transcription regulatory region DNA binding • SMAD binding • sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • histone deacetylase binding Cellular component • Ino80 complex • nuclear matrix • nucleus • PcG protein complex • transcription factor complex • cytoplasm Biological process • cell differentiation • DNA recombination • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • cellular response to UV • negative regulation of gene expression • transcription, DNA-templated • cellular response to DNA damage stimulus • double-strand break repair via homologous recombination • spermatogenesis • DNA repair • response to prostaglandin F • negative regulation of transcription from RNA polymerase II promoter • response to UV-C • positive regulation of gene expression • cellular response to interleukin-1 • chromosome organization • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • camera-type eye morphogenesis • RNA localization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7528	22632
Ensembl	ENSG00000100811	ENSMUSG00000021264
UniProt	P25490	Q00899
RefSeq (mRNA)	NM_003403	NM_009537
RefSeq (protein)	NP_003394.1	NP_033563.2
Location (UCSC)	Chr 14: 100.24 – 100.28 Mb	Chr 12: 108.79 – 108.82 Mb
PubMed search	[1]	[2]
Wikidata

YY1 (Yin Yang 1)^[3] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.^[4][5]

Function

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.^[6]

Interactions

YY1 has been shown to interact with:

References

Further reading

External links

• FactorBook YY1

PDB gallery
1ubd: CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT