Interferon regulatory factors
| Interferon regulatory factor transcription factor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 interferon regulatory factor-2 dna binding domain, nmr, minimized average structure | |||||||||
| Identifiers | |||||||||
| Symbol | IRF | ||||||||
| Pfam | PF00605 | ||||||||
| InterPro | IPR001346 | ||||||||
| SCOP | 1if1 | ||||||||
| SUPERFAMILY | 1if1 | ||||||||
| |||||||||
Interferon regulatory factors are proteins which regulate transcription of interferons (see regulation of gene expression).[1]
They are used in the JAK-STAT signaling pathway.[2]
Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence (ICS), which is located upstream of the interferon genes.[3] The remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein.[3]
Genes
See also
References
- ↑ Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie. 89 (6–7): 744–53. doi:10.1016/j.biochi.2007.01.014. PMC 2139905
. PMID 17399883. - ↑ Tsuneya Ikezu; Howard E. Gendelman (2008). Neuroimmune Pharmacology. Springer. pp. 213–. ISBN 978-0-387-72572-7. Retrieved 28 November 2010.
- 1 2 Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054.
External links
- Interferon regulatory factors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the public domain Pfam and InterPro IPR001346
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