Glycyl endopeptidase

Identifiers

Databases

PDB structures

Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya proteinase 4, PPIV, chymopapain M) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Preferential cleavage: Gly-, in proteins and small molecule substrates

This enzyme is isolated from the papaya plant, Carica papaya.

References

↑ Polgár, L. (1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochim. Biophys. Acta. 658: 262–269. doi:10.1016/0005-2744(81)90296-5. PMID 7018581.
↑ Buttle, D.J.; Kembhavi, A.A.; Sharp, S.L.; Shute, R.E.; Rich, D.H.; Barrett, A.J. (1989). "Affinity purification of the novel cysteine proteinase papaya proteinase IV and papain from papaya latex". Biochem. J. 261: 469–476. PMID 2505761.
↑ Ritonja, A.; Buttle, D.J.; Rawlings, N.D.; Turk, V.; Barrett, A.J. (1989). "Papaya proteinase IV amino acid sequence". FEBS Lett. 258: 109–112. doi:10.1016/0014-5793(89)81627-8. PMID 2591528.
↑ Buttle, D.J.; Ritonja, A.; Pearl, L.H.; Turk, V.; Barrett, A.J. (1990). "Selective cleavage of glycyl bonds by papaya proteinase IV". FEBS Lett. 260: 195–197. doi:10.1016/0014-5793(90)80101-n. PMID 2404797.
↑ Buttle, D.J.; Ritonja, A.; Dando, P.M.; Abrahamson, M.; Shaw, E.N.; Wikstrom, P.; Turk, V.; Barrett, A.J. (1990). "Interaction of papaya proteinase IV with inhibitors". FEBS Lett. 262: 58–60. doi:10.1016/0014-5793(90)80153-a. PMID 1690669.

Glycyl endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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