Gingipain K

Gingipain K
Identifiers
EC number 3.4.22.47
CAS number 159745-69-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Gingipain K (EC 3.4.22.47, Lys-gingipain, PrtP proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Endopeptidase with strict specificity for lysyl bonds

Activity of this enzyme is stimulated by glycine.

References

  1. Pike, R.; McGraw, W.; Potempa, J.; Travis, J. (1994). "Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins". J. Biol. Chem. 269: 406–411. PMID 8276827.
  2. Curtis, M.A.; Aduse, O.J.; Rangarajan, M.; Gallagher, A.; Sterne, J.A.; Reid, C.R.; Evans, H.E.; Samuelsson, B. (2002). "Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor 2". Infect. Immun. 70: 6968–6975. doi:10.1128/iai.70.12.6968-6975.2002. PMID 12438376.
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