Cicletanine

Cicletanine
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C03BX03 (WHO)
Pharmacokinetic data
Protein binding	97.3%
Biological half-life	7.9 h
Identifiers
IUPAC name 3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
CAS Number	89943-82-8^Y
PubChem (CID)	54910
ChemSpider	49583^Y
UNII	CHG7QC509W^Y
KEGG	D03487^Y
ChEMBL	CHEMBL191886^Y
ECHA InfoCard	100.158.583
Chemical and physical data
Formula	C₁₄H₁₂ClNO₂
Molar mass	261.703 g/mol
3D model (Jmol)	Interactive image
SMILES Clc1ccc(cc1)C3OCc2c3cnc(c2O)C
InChI InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3^Y Key:CVKNDPRBJVBDSS-UHFFFAOYSA-N^Y
(verify)

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.^[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.^[2]

Mechanism

It can inhibit protein kinase C.^[3]

References

↑ Jean Sassard (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 978-0-86196-313-3.
↑ Bagrov AY; Dmitrieva RI; Dorofeeva NA; et al. (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". J. Hypertens. 18 (2): 209–15. doi:10.1097/00004872-200018020-00012. PMID 10694190.
↑ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension. 41 (3): 505–11. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951.

External links

Ipsen Corporation

Antihypertensives: diuretics (C03)

Sulfonamides
(and etacrynic acid)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozolin Muzolimine Ozolinone Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Osmotic diuretics (PT, DL)

Vasopressin receptor inhibitors
(DCT and CD)

Other

Ethanol, Isopropanol, 2M2B
mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
Theobromine
Cicletanine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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