Caspase-10
| Caspase-10 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.22.63 | ||||||||
| CAS number | 189088-85-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Caspase-10 (EC 3.4.22.63, FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1beta-converting enzyme 2) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly
Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62).
References
- ↑ Chang, H.Y.; Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64: 821–846. doi:10.1128/mmbr.64.4.821-846.2000. PMID 11104820.
- ↑ Fischer, U.; Stroh, C.; Schulze-Osthoff, K. (2006). "Unique and overlapping substrate specificities of caspase-8 and caspase-10". Oncogene. 25: 152–159. doi:10.1038/sj.onc.1209015. PMID 16186808.
- ↑ Shikama, Y.; Yamada, M.; Miyashita, T. (2003). "Caspase-8 and caspase-10 activate NF-κB through RIP, NIK and IKKα kinases". Eur. J. Immunol. 33: 1998–2006. doi:10.1002/eji.200324013. PMID 12884866.
- ↑ Boatright, K.M.; Deis, C.; Denault, J.B.; Sutherlin, D.P.; Salvesen, G.S. (2004). "Activation of caspases-8 and -10 by FLIPL". Biochem. J. 382: 651–657. doi:10.1042/bj20040809. PMID 15209560.
External links
- Caspase-10 at the US National Library of Medicine Medical Subject Headings (MeSH)
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