CY-208,243

CY-208,243
Identifiers

IUPAC name 4,6,6a,7,8,12b-hexahydro-7-methylindolo(4,3-ab)-phenanthridine
CAS Number	100999-26-6^Y
PubChem (CID)	58144
ChemSpider	52380^N
Chemical and physical data
Formula	C₁₉H₁₈N₂
Molar mass	274.359 g/mol
3D model (Jmol)	Interactive image
SMILES c15c4ncc5CC2C(c1ccc4)c3ccccc3CN2C
InChI InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3/t17-,19-/m1/s1^N Key:WRNKIDLXXXIELU-IEBWSBKVSA-N^N
^NY (what is this?) (verify)

CY-208,243 is a drug which acts as a dopamine agonist selective for the D₁ subtype. Unlike most D₁-selective agonists, it shows efficacy in animal models of Parkinson's disease.^[1]^[2]^[3]^[4]^[5]

References

↑ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). "Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors". Progress in Neuro-psychopharmacology & Biological Psychiatry. 19 (4): 667–76. doi:10.1016/0278-5846(95)00110-h. PMID 8588064.
↑ Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". Behavioural Pharmacology. 6 (8): 785–793. doi:10.1097/00008877-199512000-00003. PMID 11224381.
↑ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in Neurology. 69: 239–44. PMID 8615134.
↑ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats". European Journal of Pharmacology. 460 (1): 71–4. doi:10.1016/S0014-2999(02)02881-9. PMID 12535862.
↑ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). "Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243". Behavioural Brain Research. 156 (2): 173–9. doi:10.1016/j.bbr.2004.05.019. PMID 15582103.

Dopamine receptor modulators

D₁-like

Agonists

Benzazepines 6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam

Ergolines Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride

Dihydrexidine derivatives A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine

Phenethylamines Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279

Others A-68930 Apomorphine Isocorypalmine Nuciferine Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tetrahydropalmatine

Antagonists

Typical antipsychotics Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol

Atypical antipsychotics Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (++fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine

Others Ecopipam EEDQ Metitepine (methiothepin) SCH-23390

D₂-like

Agonists

Adamantanes Amantadine Memantine Rimantadine

Aminotetralins 5-OH-DPAT 7-OH-DPAT 8-OH-PBZI Rotigotine UH-232

Ergolines Bromocriptine Cabergoline Dihydroergocryptine Epicriptine Lisuride LSD Pergolide Terguride

Dihydrexidine derivatives 2-OH-NPA Ciladopa Dihydrexidine Dinoxyline N,N-Propyldihydrexidine

Phenethylamines Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) L-Phenylalanine L-Tyrosine Melevodopa XP21279

Atypical antipsychotics Alentemol (U-66444B) Aripiprazole (+sertraline) Aripiprazole lauroxil Bifeprunox Brexpiprazole Cariprazine F-15063 Lumateperone Norclozapine RP5063

Others A-412,997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine Esketamine Flibanserin GSK-789,472 Ketamine Mesulergine Modafinil OSU-6162 Pardoprunox Phencyclidine PD-128,907 PD-168,077 PF-219,061 PF-592,379 Piribedil Pramipexole Propylnorapomorphine Pukateine Quinagolide Quinelorane Quinpirole RDS-127 Ro10-5824 Ropinirole Roxindole Salvinorin A SKF-83,959 Sumanirole Talipexole Umespirone WAY-100,635

Antagonists

Typical antipsychotics Acepromazine Acetophenazine Azaperone Benperidol Bromperidol Butaclamol Butaperazine Chloracizine Clopenthixol Chlorproethazine Chlorpromazine Chlorprothixene Ciclindole Clothixamide Clopimozide Droperidol Fluacizine Fluanisone Flucindole Fluotracen Flupentixol (flupenthixol) (+melitracen) Fluphenazine Fluprothixene Fluspirilene Haloperidol Homopipramol Lenperone Levomepromazine (methotrimeprazine) Levosulpiride Loxapine Mesoridazine Moperone Naranol Nemonapride Penfluridol Perathiepin Perazine Pericyazine (periciazine) Perphenazine (+amitriptyline) Piflutixol (pifluthixol) Pimozide Pipamperone Prochlorperazine Promazine Prothipendyl Spiperone (spiroperidol) Sulforidazine Sulpiride Sultopride Teflutixol Thiopropazate Thioproperazine Thioridazine Thiothixene Timiperone Trifluoperazine (+tranylcypromine) Triflupromazine Trifluperidol Zetidoline Zuclopenthixol

Atypical antipsychotics Amisulpride Asenapine BL-1020 Blonanserin Carpipramine Cinuperone Clocapramine Clorotepine Clotiapine (clothiapine) Clozapine Cyamemazine DHA-clozapine Dixyrazine Elopiprazole Flumezapine Fluperlapine Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone Zotepine

Antiemetics/gastroprokinetics/sedatives Aceprometazine AS-8112 Alimemazine Alizapride Benzquinamide Bromopride Clebopride Domperidone Eticlopride Hydroxyzine Itopride Metoclopramide Metopimazine Promethazine Thiethylperazine Trimethobenzamide

Antidepressants Amoxapine Nefazodone Opipramol Propiomazine Trimipramine

Others Azapride Buspirone Desmethoxyfallypride EEDQ F-15063 Fallypride Fananserin Fenfluramine GSK-789,472 Iodobenzamide Isocorypalmine L-741,626 L-745,870 Levofenfluramine LEK-8829 Metergoline Metitepine (methiothepin) N-Methylspiperone Nafadotride Nuciferine PNU-99,194 Pridopidine Raclopride Sarizotan SB-277,011-A Seridopidine Sonepiprazole Spiroxatrine Stepholidine SV-293 Tetrahydropalmatine Tiapride UH-232 Yohimbine

See also: Adrenergics

Melatonergics

Serotonergics

Monoamine reuptake and release modulators

Monoamine metabolism modulators

Monoamine neurotoxins

This article is issued from Wikipedia - version of the 5/28/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.