Cyclin E2

cyclin E2
Identifiers
Symbol	CCNE2
Entrez	9134
HUGO	1590
OMIM	603775
RefSeq	NM_057749
UniProt	O96020
Other data
Locus	Chr. 8 q22.1

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).^[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.^[1]

References

1 2 Gudas, Jean M.; Payton, Marc; Thukral, Sushil; Chen, Eddy; Bass, Michael; Robinson, Murray O.; Coats, Steve (1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.

Cell cycle proteins

Cyclin

A (A1, A2)
B (B1, B2, B3)
D (D1, D2, D3)
E (E1, E2)

CDK

CDK inhibitor

INK4a/ARF (p14arf/p16, p15, p18, p19)
cip/kip (p21, p27, p57)

P53 p63 p73 family

Other

Phases and
checkpoints

Interphase	G₁ phase S phase G₂ phase

M phase	Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis

Cell cycle checkpoints	Restriction point Spindle checkpoint Postreplication checkpoint

Other cellular phases	Apoptosis G₀ phase Meiosis

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