Cyclin D3

CCND3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases CCND3
External IDs MGI: 88315 HomoloGene: 20419 GeneCards: CCND3
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

896

12445

Ensembl

ENSG00000112576

ENSMUSG00000034165

UniProt

P30281

P30282

RefSeq (mRNA)

NM_001081635
NM_001081636
NM_007632

RefSeq (protein)

NP_001075104.1
NP_001075105.1
NP_031658.1

Location (UCSC) Chr 6: 41.93 – 42.05 Mb Chr 17: 47.51 – 47.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.[3]

Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.[4]

Clinical significance

Mutations in CCND3 are implicated in cases of breast cancer.[5]

Interactions

Cyclin D3 has been shown to interact with:

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (August 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics. 13 (3): 565–74. doi:10.1016/0888-7543(92)90126-D. PMID 1386335.
  4. ↑ "Entrez Gene: CCND3 cyclin D3".
  5. ↑ "Comprehensive molecular portraits of human breast tumours". Nature. Nature Publishing Group. 490 (7418): 61–70. 2012. doi:10.1038/nature11412. PMC 3465532Freely accessible. PMID 23000897.
  6. 1 2 Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988Freely accessible. PMID 14641107.
  7. ↑ Zhang S, Cai M, Zhang S, Xu S, Chen S, Chen X, Chen C, Gu J (2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. PMID 12082095.
  8. 1 2 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  9. 1 2 3 Lin J, Jinno S, Okayama H (2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene. 20 (16): 2000–9. doi:10.1038/sj.onc.1204375. PMID 11360184.
  10. 1 2 Zhang Q, Wang X, Wolgemuth DJ (1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology. 140 (6): 2790–800. doi:10.1210/endo.140.6.6756. PMID 10342870.
  11. 1 2 Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L (2003). "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II". J. Biol. Chem. 278 (8): 6355–62. doi:10.1074/jbc.M210697200. PMID 12482873.
  12. ↑ Meyerson M, Harlow E (1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Mol. Cell. Biol. 14 (3): 2077–86. PMC 358568Freely accessible. PMID 8114739.
  13. ↑ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.

Further reading

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