Tentoxilysin

Tentoxilysin
Identifiers
EC number 3.4.24.68
CAS number 107231-12-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Tentoxilysin (EC 3.4.24.68, tetanus neurotoxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of -Gln76-Phe- bond in synaptobrevin

This cinc enzyme produced by Clostridium tetani.

References

  1. Fujii, N.; Kimura, K.; Yashiki, T.; Tsuzuki, K.; Moriishi, K.; Yokosawa, N.; Syuto, B.; Oguma, K. (1992). "A zinc-protease specific domain in botulinum and tetanus neurotoxins". Microbiol. Intern. 36 (3): 213–220. PMID 1376283.
  2. Schiavo, G.; Benfenati, F.; Poulain, B.; Rossetto, O.; Polverino de Laureto, P.; DasGupta, B.R.; Montecucco, C. (1992). "Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin". Nature. 359 (6398): 832–834. doi:10.1038/359832a0. PMID 1331807.
  3. Schiavo, G.; Rossetto, O.; Santucci, A.; DasGupta, B.R.; Montecucco, C. (1992). "Botulinum neurotoxins are zinc proteins". J. Biol. Chem. 267 (33): 23479–23483. PMID 1429690.
  4. Montecucco, C.; Schiavo, G. (1994). "Mechanism of action of tetanus and botulinum neurotoxins". Mol. Microbiol. 13 (1): 1–8. doi:10.1111/j.1365-2958.1994.tb00396.x. PMID 7527117.
  5. Schiavo, G.; Montecucco, C. (1995). "Tetanus and botulism neurotoxins". Methods Enzymol. 248: 643–652. doi:10.1016/0076-6879(95)48041-2. PMID 7674951.
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