ADAM11

ADAM11
Identifiers
Aliases ADAM11, MDC, ADAM metallopeptidase domain 11
External IDs MGI: 1098667 HomoloGene: 7614 GeneCards: ADAM11
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

4185

11488

Ensembl

ENSG00000073670

ENSMUSG00000020926

UniProt

O75078

Q9R1V4

RefSeq (mRNA)

NM_002390
NM_001318933

NM_001110778
NM_009613

RefSeq (protein)

NP_002381.2

NP_033743.2

Location (UCSC) Chr 17: 44.76 – 44.78 Mb Chr 11: 102.76 – 102.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.[3][4]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040.
  4. 1 2 "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11".

Further reading

External links


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