Setastine
 | |
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | 59767-13-4 |
| PubChem (CID) | 43082 |
| ChemSpider | 39258 |
| UNII |
6G3OCF528J  |
| Chemical and physical data | |
| Formula | C22H28ClNO |
| Molar mass | 357.92 g/mol |
| 3D model (Jmol) | Interactive image |
| |
Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.[1][2]
Pharmacology
Pharmacodynamics
Setastine acts as a highly selective H1 receptor antagonist.[3] It has no anticholinergic, antiadrenergic, or antiserotonergic effects.
Pharmacokinetics
Setastine penetrates the blood-brain-barrier only weakly, hence, it is not sedating or is only mildly so.[3]
See also
References
- ↑ Lantos A; Tóth A; Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica (English Edition). 39 (1): 22–4. PMID 1677500.
- ↑ Hirschberg A; Ribári O; Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica (English Edition). 37 (4): 202–4. PMID 2576575.
- 1 2 Porszász J, Varga F, Porszász KG, et al. (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–5. PMID 1982751.
This article is issued from Wikipedia - version of the 9/25/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.