P2RY1

P2RY1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases P2RY1, P2Y1, purinergic receptor P2Y1
External IDs MGI: 105049 HomoloGene: 1926 GeneCards: P2RY1
Targeted by Drug
adenosine diphosphate, adenosine triphosphate, adenosine 3',5'-diphosphate, suramin[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5028

18441

Ensembl

ENSG00000169860

ENSMUSG00000027765

UniProt

P47900

P49650

RefSeq (mRNA)

NM_002563

NM_001282016
NM_008772

RefSeq (protein)

NP_002554.1

NP_001268945.1
NP_032798.1

Location (UCSC) Chr 3: 152.83 – 152.84 Mb Chr 3: 61 – 61.01 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[4]

Function

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[5]

See also

References

  1. "Drugs that physically interact with P2Y purinoceptor 1 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
  5. "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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