Oligopeptidase A

Oligopeptidase A
Identifiers
EC number 3.4.24.70
CAS number 394250-11-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Oligopeptidase A (EC 3.4.24.70, 68000-M signalpeptide hydrolase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved, but not Z-(Gly)5

This enzyme is known from Escherichia coli and Salmonella typhimurium.

References

  1. Novak, P.; Dev, I.K. (1988). "Degradation of a signal peptide by protease IV and oligopeptidase A". J. Bacteriol. 170: 5067–5075. PMID 3053642.
  2. Conlin, C.A.; Vimr, E.R.; Miller, C.G. (1992). "Oligopeptidase A is required for normal phage P22 development". J. Bacteriol. 174: 5869–5880. PMID 1522065.
  3. Conlin, C.A.; Trun, N.J.; Silhavy, T.J.; Miller, C.G. (1992). "Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene". J. Bacteriol. 174: 5881–5887. PMID 1325967.
  4. Conlin, C.A.; Miller, C.G. (1995). "Oligopeptidase A and peptidyl-dipeptidase of Escherichia and Salmonella". Methods Enzymol. 248: 567–579. doi:10.1016/0076-6879(95)48036-6. PMID 7674945.
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