Meprin B
| Meprin B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.63 | ||||||||
| CAS number | 150679-52-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Meprin B (EC 3.4.24.63, meprin-b) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5-Leu-, -Leu6-Cys-, -Ala14-Leu- and -Cys19-Gly- bonds in insulin B chain
This membrane-bound metalloendopeptidase is present in mouse intestines.
References
- ↑ Kounnas, M.Z.; Wolz, R.L.; Gorbea, C.M.; Bond, J.S. (1991). "Meprin-A and -B. Cell surface endopeptidases of the mouse kidney". J. Biol. Chem. 266: 17350–17357. PMID 1894622.
- ↑ Gorbea, C.M.; Marchand, P.; Jiang, W.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Bond, J.S. (1993). "Cloning, expression, and chromosomal localization of the mouse meprin β subunit". J. Biol. Chem. 268: 21035–21043. PMID 8407940.
- ↑ Johnson, G.D.; Hersh, L.B. (1994). "Expression of meprin subunit precursors. Membrane anchoring through the β subunit and mechanism of zymogen activation". J. Biol. Chem. 269: 7682–7688. PMID 7510289.
- ↑ Wolz, R.L.; Bond, J.S. (1995). "Meprins A and B". Methods Enzymol. 248: 325–345. doi:10.1016/0076-6879(95)48022-6. PMID 7674930.
External links
- Meprin B at the US National Library of Medicine Medical Subject Headings (MeSH)
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