Leucolysin

Leucolysin
Identifiers
EC number 3.4.24.6
CAS number 72561-03-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Leucolysin (EC 3.4.24.6, Leucostoma neutral proteinase, Leucostoma peptidase A) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of Phe1-Val, His5-Leu, Ala14-Leu, Gly20-Glu, Gly23-Phe and Phe24-Phe bonds in insulin B chain as well as N-blocked dipeptides

This enzyme is isolated from the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).

References

  1. Wagner, F.W., Spiekerman, A.M. and Prescott, J.M. (1968). "Leucostoma peptidase A. Isolation and physical properties". J. Biol. Chem. 243: 4486–4493. PMID 5684005.
  2. Spiekerman, A.M., Fredericks, K.K., Wagner, F.W. and Prescott, J.M. (1973). "Leucostoma peptidase A: a metalloprotease from snake venom". Biochim. Biophys. Acta. 293: 464–475. doi:10.1016/0005-2744(73)90353-7. PMID 4711816.
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