Leishmanolysin

Leishmanolysin
Identifiers
EC number 3.4.24.36
CAS number 161052-06-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Leishmanolysin (EC 3.4.24.36, promastigote surface endopeptidase, glycoprotein gp63, Leishmania metalloproteinase, surface acid proteinase, promastigote surface protease) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-Leu-Lys-Lys-

This membrane-bound glycoprotein is present in the promastigote of various species of Leishmania protozoans.

References

  1. Button, L.L.; McMaster, W.R. (1988). "Molecular cloning of the major surface antigen of Leishmania". J. Exp. Med. 167: 724–729. doi:10.1084/jem.167.2.724. PMID 3346625.
  2. Bouvier, J.; Cordier, C.; Vogel, H.; Reichelt, R.; Etges, R. (1989). "Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase". Mol. Biochem. Parasitol. 37: 235–246. doi:10.1016/0166-6851(89)90155-2. PMID 2608099.
  3. Chaudhuri, G.; Chaudhuri, M.; Pan, A.; Chang, K.-P. (1989). "Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages". J. Biol. Chem. 264: 7483–7489. PMID 2708373.
  4. Bouvier, J.; Schneider, P.; Etges, R.; Bordier, C. (1990). "Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania". Biochemistry. 29: 10113–10119. doi:10.1021/bi00495a015. PMID 2271643.
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