Fragilysin
| Fragilysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.74 | ||||||||
| CAS number | 188596-63-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Fragilysin (EC 3.4.24.74, Bacteroides fragilis (entero)toxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Broad proteolytic specificity, bonds hydrolysed including -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly
It is thought to be a cause of diarrhoea in animals and humans.
References
- ↑ Moncrief, J.S.; Obiso, R.; Jr.; Barroso, L.A.; Kling, J.J.; Wright, R.L.; Van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D. (1995). "The enterotoxin of Bacteroides fragilis is a metalloprotease". Infect. Immun. 63: 175–181. PMID 7806355.
- ↑ Obiso, R.J.; Jr.; Lyerly, D.M.; Van Tassell, R.L.; Wilkins, T.D. (1995). "Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo". Infect. Immun. 63: 3820–3826. PMID 7558286.
- ↑ Donelli, G.; Fabbri, A.; Fiorentini, C. (1996). "Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells". Infect. Immun. 64: 113–119. PMID 8557328.
- ↑ Koshy, S.S.; Montrose, M.H.; Sears, C.L. (1996). "Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis". Infect. Immun. 64: 5022–5028. PMID 8945541.
- ↑ Kling, J.J.; Wright, R.L.; Moncrief, J.S.; Wilkins, T.D. (1997). "Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis". FEMS Microbiol. Lett. 146: 279–284. doi:10.1016/s0378-1097(96)00488-0. PMID 9011050.
External links
- Fragilysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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