Endothelin-converting enzyme 1
| Endothelin-converting enzyme 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.71 | ||||||||
| CAS number | 138238-81-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1
This metalloendopeptidase belongs to the peptidase family M13.
References
- ↑ Takahashi, M.; Matsushita, Y.; Iijima, Y.; Tanzawa, K. (1993). "Purification and characterization of endothelin-converting enzyme from rat lung". J. Biol. Chem. 268: 21394–21398. PMID 8407980.
- ↑ Shimada, K.; Takahashi, M.; Tanzawa, K. (1994). "Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells". J. Biol. Chem. 269: 18275–18278. PMID 8034569.
- ↑ Xu, D.; Emoto, N.; Giaid, A.; Slaughter, C.; Kaw, S.; DeWit, D.; Yanagisawa, M. (1994). "ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1". Cell. 78: 473–485. doi:10.1016/0092-8674(94)90425-1. PMID 8062389.
External links
- Endothelin-converting enzyme 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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