Atrolysin C
| Atrolysin C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.42 | ||||||||
| CAS number | 158886-17-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Atrolysin C (EC 3.4.24.42, Crotalus atrox metalloendopeptidase c, hemorrhagic toxin c and d) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1
This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).
References
- ↑ Bjarnason, J.B.; Tu, A.T. (1978). "Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17: 3395–3404. doi:10.1021/bi00609a033. PMID 210790.
- ↑ Fox, J.W.; Campbell, R.; Beggerly, L.; Bjarnason, J.B. (1986). "Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom". Eur. J. Biochem. 156 (1): 65–72. doi:10.1111/j.1432-1033.1986.tb09549.x. PMID 3514216.
- ↑ Bjarnason, J.B.; Fox, J.W. (1987). "Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom". Biochim. Biophys. Acta. 911 (3): 356–363. doi:10.1016/0167-4838(87)90077-x. PMID 3101740.
- ↑ Mori, N.; Nikai, T.; Sugihara, H.; Tu, A.T. (1987). "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom". Arch. Biochem. Biophys. 253 (1): 108–121. doi:10.1016/0003-9861(87)90643-6. PMID 2949699.
- ↑ Shannon, J.D.; Baramova, E.N.; Bjarnason, J.B.; Fox, F.W. (1989). "Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin". J. Biol. Chem. 264 (20): 11575–11583. PMID 2745407.
- ↑ Takeya, H.; Onikura, A.; Nikai, T.; Sugihara, H.; Iwanaga, S. (1990). "2, Primary structure of a hemorrhagic metalloproteinase, HT-isolated from the venom of Crotalus ruber ruber". J. Biochem. (Tokyo). 108 (5): 711–719. PMID 2081731.
External links
- Atrolysin C at the US National Library of Medicine Medical Subject Headings (MeSH)
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