Atrolysin A
| Atrolysin A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.1 | ||||||||
| CAS number | 37288-82-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Atrolysin A (EC 3.4.24.1, Crotalus atrox metalloendopeptidase a, hemorrhagic toxin a, Crotalus atrox alpha-proteinase, Crotalus atrox proteinase, bothropasin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of Asn3-Gln, His5-Leu, His10-Leu, Ala14-Leu and Tyr16-Leu in insulin B chain; removes C-terminal Leu from small peptides
This endopeptidase is one of six hemorrhagic toxins in the venom of western diamondback rattlesnake.
References
- ↑ Bjarnason, J.B.; Tu, A.T. (1978). "Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17: 3395–3404. doi:10.1021/bi00609a033. PMID 210790.
- ↑ Mori, N.; Nikai, T.; Sugihara, H.; Tu, A.T. (1987). "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom". Arch. Biochem. Biophys. 253 (1): 108–121. doi:10.1016/0003-9861(87)90643-6. PMID 2949699.
- ↑ Bjarnason, J.B.; Hamilton, D.; Fox, J.W. (1988). "Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom". Biol. Chem. Hoppe-Seyler. 369: 121–129. PMID 3060135.
- ↑ Bjarnason, J.B.; Fox, J.W. (1989). "Hemorrhagic toxins from snake venoms". J. Toxicol. Toxin Rev. 7: 121–209. doi:10.3109/15569548809059729.
External links
- Atrolysin A at the US National Library of Medicine Medical Subject Headings (MeSH)
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