ADAMTS-4 endopeptidase
| ADAMTS-4 endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.82 | ||||||||
| CAS number | 147172-61-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme.[1] This enzyme catalyses the following chemical reaction
- Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan
This enzyme belongs to the peptidase family M12.
References
- ↑ Westling, J.; Fosang, A.J.; Last, K.; Thompson, V.P.; Tomkinson, K.N.; Hebert, T.; McDonagh, T.; Collins-Racie, L.A.; LaVallie, E.R.; Morris, E.A.; Sandy, J.D. (2002). "ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain". J. Biol. Chem. 277: 16059–16066. doi:10.1074/jbc.M108607200. PMID 11854269.
External links
- ADAMTS-4 endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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