Xenobiotic-transporting ATPase

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (xenobiotic-exporting). Other names in common use include multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, and ATP phosphohydrolase (steroid-exporting).

References

Bellamy WT (1996). "P-glycoproteins and multidrug resistance". Annu. Rev. Pharmacol. Toxicol. 36: 161–83. doi:10.1146/annurev.pa.36.040196.001113. PMID 8725386.
Oude Elferink RP; Ottenhoff, R; Van Wijland, MJ; Van Nieuwkerk, C; Groen, AK; Oude Elferink, RP (1996). "Influence of bile salts on hepatic mdr2 P-glycoprotein expression". Adv. Enzyme. Regul. 36: 351–63. doi:10.1016/0065-2571(95)00019-4. PMID 8869755.
Keppler D, Konig J, Buchler M (1997). "The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes". Adv. Enzyme. Regul. 37: 321–33. doi:10.1016/S0065-2571(96)00013-1. PMID 9381978.
Loe DW, Deeley RG, Cole SP (1998). "Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione". Cancer. Res. 58 (22): 5130–6. PMID 9823323.
van Veen HW, Konings WN (1998). "The ABC family of multidrug transporters in microorganisms". Biochim. Biophys. Acta. 1365 (1–2): 31–6. doi:10.1016/S0005-2728(98)00039-5. PMID 9693718.
Griffiths JK; Sansom CE. "The Transporter Factsbook, Academic Press, San Diego, 1998".
Prasad R, De Wergifosse P, Goffeau A, Balzi E (1995). "Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals". Curr. Genet. 27 (4): 320–9. doi:10.1007/BF00352101. PMID 7614555.
Yamasaki M; Taguchi, Y; Arioka, M; Kadokura, H; Takatsuki, A; Yoda, K; Yamasaki, M (1995). "bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily". J. Bacteriol. 177 (6): 1536–43. PMC 176770. PMID 7883711.
Mahe Y, Lemoine Y, Kuchler K (1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo". J. Biol. Chem. 271 (41): 25167–72. doi:10.1074/jbc.271.41.25167. PMID 8810273.

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B

Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2

Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4

H+/K+ (3.6.3.10)	ATP4A

Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_αi GNAI1 GNAI2 GNAI3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13 Transducin GNAT1 GNAT2 Gustducin GNAT3

3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK

3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic

3.6.5.5-6: Polymerization motors	Dynamin Tubulin

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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