X-Trp aminopeptidase

Xaa-Trp aminopeptidase
Identifiers
EC number 3.4.11.16
CAS number 137010-33-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Xaa-Trp aminopeptidase (EC 3.4.11.16, aminopeptidase W, aminopeptidase X-Trp) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Release of a variety of N-terminal residues (especially glutamate and leucine) from peptides, provided tryptophan (or at least phenylalanine or tyrosine) is the penultimate residue. Also acts on Glu!Trp, Leu!Trp and a number of other dipeptides

This glycoprotein containingw Zn2+.

References

  1. Gee, N.S.; Kenny, A.J. (1985). "Proteins of the kidney microvillar membrane. The 130kDa protein in pig kidney, recognised by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity". Biochem. J. 230: 753–764. PMID 4062876.
  2. Gee, N.S.; Kenny, A.J. (1987). "Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W". Biochem. J. 246: 97–102. PMID 2890346.
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