WNT3A

Identifiers

External IDs

MGI: 98956 HomoloGene: 22528 GeneCards: WNT3A

Gene ontology
Molecular function	• protein domain specific binding • receptor binding • co-receptor binding • frizzled binding • frizzled-2 binding • protein binding • transcription coactivator activity • receptor agonist activity
Cellular component	• endocytic vesicle membrane • endoplasmic reticulum lumen • extracellular region • extracellular fluid • cell surface • extracellular exosome • Wnt-Frizzled-LRP5/6 complex • early endosome membrane • proteinaceous extracellular matrix • plasma membrane • Golgi lumen • presynapse • synapse
Biological process	• positive regulation of transcription regulatory region DNA binding • somitogenesis • cellular response to retinoic acid • hemopoiesis • positive regulation of protein phosphorylation • Wnt signaling pathway involved in forebrain neuroblast division • positive regulation of skeletal muscle tissue development • positive regulation of receptor internalization • axis elongation involved in somitogenesis • positive regulation of collateral sprouting in absence of injury • mammary gland development • platelet activation • heart looping • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein localization to plasma membrane • cardiac muscle cell fate commitment • mesoderm development • cell proliferation in forebrain • positive regulation of mesodermal cell fate specification • negative regulation of fat cell differentiation • canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • regulation of microtubule cytoskeleton organization • negative regulation of dopaminergic neuron differentiation • cell proliferation in midbrain • in utero embryonic development • negative regulation of axon extension involved in axon guidance • positive regulation of peptidyl-serine phosphorylation • positive regulation of transcription, DNA-templated • regulation of axonogenesis • positive regulation of B cell proliferation • post-anal tail morphogenesis • synapse assembly • positive regulation of cardiac muscle cell differentiation • palate development • negative regulation of neuron projection development • paraxial mesodermal cell fate commitment • negative regulation of neurogenesis • positive regulation of protein tyrosine kinase activity • positive regulation of sequence-specific DNA binding transcription factor activity • extracellular matrix organization • positive regulation of neural precursor cell proliferation • synaptic vesicle recycling • osteoblast differentiation • skeletal muscle cell differentiation • canonical Wnt signaling pathway • COP9 signalosome assembly • dorsal/ventral neural tube patterning • positive regulation of protein binding • platelet aggregation • midbrain development • positive regulation of protein kinase activity • positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of hepatocyte proliferation • neurogenesis • spinal cord association neuron differentiation • axonogenesis • positive regulation of cytokine production • positive regulation of dermatome development • positive regulation of catenin import into nucleus • somatic stem cell division • positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation • axon guidance • multicellular organism development • cellular protein localization • determination of left/right symmetry • inner ear morphogenesis • positive regulation of cell proliferation • regulation of cell differentiation • hippocampus development • negative regulation of heart induction by canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • anterior/posterior pattern specification • positive regulation of calcium ion transmembrane transport • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • beta-catenin destruction complex disassembly • neuron differentiation • Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


89780


22416

Ensembl


ENSG00000154342


ENSMUSG00000009900

UniProt


P56704


P27467

RefSeq (mRNA)


NM_033131


NM_009522

RefSeq (protein)


NP_149122.1


NP_033548.1

Location (UCSC)

Chr 1: 228.01 – 228.06 Mb

Chr 11: 59.25 – 59.29 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.^[3]^[4]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc^[5] and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem Biophys Res Commun. 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
1 2 "Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A".
↑ http://www.jbc.org/content/280/25/24004.full

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
Huguet EL, McMahon JA, McMahon AP, et al. (1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.". Cancer Res. 54 (10): 2615–21. PMID 8168088.
Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster.". Int. J. Mol. Med. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID 11836627.
Filali M, Cheng N, Abbott D, et al. (2002). "Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter.". J. Biol. Chem. 277 (36): 33398–410. doi:10.1074/jbc.M107977200. PMID 12052822.
Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hino S, Michiue T, Asashima M, Kikuchi A (2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.". J. Biol. Chem. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519.
Qiang YW, Endo Y, Rubin JS, Rudikoff S (2003). "Wnt signaling in B-cell neoplasia.". Oncogene. 22 (10): 1536–45. doi:10.1038/sj.onc.1206239. PMID 12629517.
Hocevar BA, Mou F, Rennolds JL, et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2).". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
Liu G, Bafico A, Harris VK, Aaronson SA (2003). "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.". Mol. Cell. Biol. 23 (16): 5825–35. doi:10.1128/MCB.23.16.5825-5835.2003. PMC 166321. PMID 12897152.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Swiatek W, Tsai IC, Klimowski L, et al. (2004). "Regulation of casein kinase I epsilon activity by Wnt signaling.". J. Biol. Chem. 279 (13): 13011–7. doi:10.1074/jbc.M304682200. PMID 14722104.
Zilberberg A, Yaniv A, Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.". J. Biol. Chem. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Capurro MI, Shi W, Sandal S, Filmus J (2006). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.". J. Biol. Chem. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID 16227623.
Thrasivoulou C, Millar M & Ahmed A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. doi:10.1074/jbc.M112.437913. PMID 24158438.

Signaling pathway: Wnt signaling pathway

Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16

Receptor	Frizzled LRP5 LRP6

Second messenger	Dishevelled GSK-3 APC Beta-catenin

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WNT3A

References

Further reading