Very-long-chain (3R)-3-hydroxyacyl-(acyl-carrier protein) dehydratase

Very-long-chain (3R)-3-hydroxyacyl-(acyl-carrier protein) dehydratase (EC 4.2.1.134, PHS1 (gene), PAS2 (gene)) is an enzyme with systematic name very-long-chain (3R)-3-hydroxyacyl-(acyl-carrier protein) hydro-lyase.^[1]^[2] This enzyme catalyses the following chemical reaction

a very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein]

\rightleftharpoons

a very-long-chain trans-2,3-dehydroacyl-[acyl-carrier protein] + H2O

This is the third component of the elongase.

References

↑ Bach, L.; Michaelson, L.V.; Haslam, R.; Bellec, Y.; Gissot, L.; Marion, J.; Da Costa, M.; Boutin, J.P.; Miquel, M.; Tellier, F.; Domergue, F.; Markham, J.E.; Beaudoin, F.; Napier, J.A.; Faure, J.D. (2008). "The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO₂ is essential and limiting for plant development". Proc. Natl. Acad. Sci. USA. 105: 14727–14731. doi:10.1073/pnas.0805089105. PMID 18799749.
↑ Kihara, A.; Sakuraba, H.; Ikeda, M.; Denpoh, A.; Igarashi, Y. (2008). "Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation". J. Biol. Chem. 283: 11199–11209. doi:10.1074/jbc.m708993200. PMID 18272525.

External links

Very-long-chain (3R)-3-hydroxyacyl-(acyl-carrier protein) dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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