Valienamine
 | |
| Names | |
|---|---|
| IUPAC name
(1S,2S,3R,6S)-6-amino-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol | |
| Identifiers | |
38231-86-6  | |
| 3D model (Jmol) | Interactive image |
| ChEMBL | ChEMBL1230806 |
| ChemSpider | 168149  |
| PubChem | 193758 |
| |
| |
| Properties | |
| C7H13NO4 | |
| Molar mass | 175.18 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Valienamine is a C-7 aminocyclitol found as a substructure of pseudooligosaccharides such as the antidiabetic drug acarbose[1] and the antibiotic validamycin. It can be found in Actinoplanes species.[2]
It is an intermediate formed by microbial degradation of validamycins.[3]
References
- ↑ Laube, Heiner (March 2002). "Acarbose An Update of Its Therapeutic Use in Diabetes Treatment". Clinical Drug Investigation. 22 (3): 141–156. doi:10.2165/00044011-200222030-00001.
- ↑ Zhang CS, Stratmann A, Block O, et al. (June 2002). "Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway". J. Biol. Chem. 277 (25): 22853–62. doi:10.1074/jbc.M202375200. PMID 11937512.
- ↑ CID 193758 from PubChem
External links
This article is issued from Wikipedia - version of the 7/21/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.