Unsaturated chondroitin disaccharide hydrolase

Unsaturated chondroitin disaccharide hydrolase
Identifiers
EC number 3.2.1.180
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Unsaturated chondroitin disaccharide hydrolase (EC 3.2.1.180, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic name beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S hydrolase.[1][2] This enzyme catalyses the following chemical reaction

beta-D-4-deoxy-Delta4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate

The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides.

References

  1. Maruyama, Y., Nakamichi, Y., Itoh, T., Mikami, B., Hashimoto, W. and Murata, K. (2009). "Substrate specificity of streptococcal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan". J. Biol. Chem. 284: 18059–18069. doi:10.1074/jbc.m109.005660. PMID 19416976.
  2. Nakamichi, Y., Maruyama, Y., Mikami, B., Hashimoto, W. and Murata, K. (2011). "Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups". J. Biol. Chem. 286: 6262–6271. doi:10.1074/jbc.m110.182618. PMID 21147778.
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