Tobamovirus internal ribosome entry site (IRES)
| Tobamovirus internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_Tobamo | |
| Identifiers | |
| Symbol | IRES_Tobamo |
| Alt. Symbols | Tobamo_IRES |
| Rfam | RF00225 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | 0043022 |
| SO | 0000243 |
The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent translation of mRNA in the host cell.[1] The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[2]
See also
References
- ↑ Ivanov, PA; Karpova OV; Skulachev MV; Tomashevskaya OL; Rodionova NP; Dorokhov YuL; Atabekov JG (1997). "A tobamovirus genome that contains an internal ribosome entry site functional in vitro". Virology. 232 (1): 32–43. doi:10.1006/viro.1997.8525. PMID 9185586.
- ↑ Kolupaeva, VG; Pestova TV; Hellen CU (2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049
. PMID 11142379.
External links
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