Thermospermine synthase

Thermospermine synthase
Identifiers
EC number 2.5.1.79
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Thermospermine synthase (EC 2.5.1.79, TSPMS, ACL5, SAC51) is an enzyme with systematic name S-adenosylmethioninamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing).[1][2][3] This enzyme catalyses the following chemical reaction

S-adenosylmethioninamine + spermidine S-methyl-5'-thioadenosine + thermospermine + H+

This enzyme is required for correct xylem specification through regulation of the lifetime of the xylem elements.

References

  1. Romer, P.; Faltermeier, A.; Mertins, V.; Gedrange, T.; Mai, R.; Proff, P. (2008). "Investigations about N-aminopropyl transferases probably involved in biomineralization". J. Physiol. Pharmacol. 59 Suppl 5: 27–37. PMID 19075322.
  2. Knott, J.M.; Romer, P.; Sumper, M. (2007). "Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine". FEBS Lett. 581 (16): 3081–3086. doi:10.1016/j.febslet.2007.05.074. PMID 17560575.
  3. Muniz, L.; Minguet, E.G.; Singh, S.K.; Pesquet, E.; Vera-Sirera, F.; Moreau-Courtois, C.L.; Carbonell, J.; Blazquez, M.A.; Tuominen, H. (2008). "ACAULIS5 controls Arabidopsis xylem specification through the prevention of premature cell death". Development. 135 (15): 2573–2582. doi:10.1242/dev.019349. PMID 18599510.
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