TRNA pseudouridine55 synthase
| TRNA pseudouridine55 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.25 | ||||||||
| CAS number | 430429-15-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA pseudouridine55 synthase (EC 5.4.99.25, TruB, aCbf5, Pus4, YNL292w (gene), Psi55 tRNA pseudouridine synthase, tRNA:Psi55-synthase, tRNA pseudouridine 55 synthase, tRNA:pseudouridine-55 synthase, Psi55 synthase, tRNA Psi55 synthase, tRNA:Psi55 synthase, tRNA-uridine55 uracil mutase, Pus10, tRNA-uridine54/55 uracil mutase) is an enzyme with systematic name tRNA-uridine55 uracil mutase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- tRNA uridine55 tRNA pseudouridine55
Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules.
References
- ↑ Nurse, K.; Wrzesinski, J.; Bakin, A.; Lane, B.G.; Ofengand, J. (1995). "Purification, cloning, and properties of the tRNA Ψ55 synthase from Escherichia coli". RNA. 1: 102–112. PMID 7489483.
- ↑ Becker, H.F.; Motorin, Y.; Planta, R.J.; Grosjean, H. (1997). "The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of Ψ55 in both mitochondrial and cytoplasmic tRNAs". Nucleic Acids Res. 25: 4493–4499. doi:10.1093/nar/25.22.4493. PMID 9358157.
- ↑ Pienkowska, J.; Wrzesinski, J.; Szweykowska-Kulinska, Z. (1998). "A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases". Acta Biochim. Pol. 45: 745–754. PMID 9918501.
- ↑ Chaudhuri, B.N.; Chan, S.; Perry, L.J.; Yeates, T.O. (2004). "Crystal structure of the apo forms of Ψ55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft". J. Biol. Chem. 279: 24585–24591. doi:10.1074/jbc.m401045200. PMID 15028724.
- ↑ Hoang, C.; Hamilton, C.S.; Mueller, E.G.; Ferre-D'Amare, A.R. (2005). "Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain". Protein Sci. 14: 2201–2206. doi:10.1110/ps.051493605. PMID 15987897.
- ↑ Gurha, P.; Gupta, R. (2008). "Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA". RNA. 14: 2521–2527. doi:10.1261/rna.1276508. PMID 18952823.
External links
- TRNA pseudouridine55 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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