tRNA-pseudouridine synthase I

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is tRNA-uridine uracilmutase. Other names in common use include tRNA-uridine isomerase, tRNA pseudouridylate synthase I, transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1VS3, 2NQP, 2NR0, and 2NRE.

References

Arena F, Ciliberto G, Ciampi S, Cortese R (1978). "Purification of pseudouridylate synthetase I from Salmonella typhimurium". Nucleic. Acids. Res. 5 (12): 4523–36. doi:10.1093/nar/5.12.4523. PMC 342770. PMID 370771.
Kammen HO, Marvel CC, Hardy L, Penhoet EE (1988). "Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I". J. Biol. Chem. 263 (5): 2255–63. PMID 3276686.

Isomerase: mutases (EC 5.4)

5.4.1 Acyl Groups	Lysolecithin acylmutase Precorrin-8X methylmutase

5.4.2 Phosphomutases	Phosphoglycerate mutase Bisphosphoglycerate mutase Phosphoglucomutase Phosphomannomutase PMM1 PMM2

5.4.99 Other groups	Methylmalonyl-CoA mutase Lanosterol synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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