TFEC

TFEC

Identifiers

TFEC, TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L, transcription factor EC

External IDs

MGI: 1333760 HomoloGene: 32148 GeneCards: TFEC

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • DNA binding • transcription coactivator activity • protein binding • protein dimerization activity • transcription corepressor activity
Cellular component	• cytoplasm • nucleus • nucleoplasm
Biological process	• cellular response to heat • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


22797


21426


ENSG00000105967


ENSMUSG00000029553


O14948


Q9WTW4

RefSeq (mRNA)


NM_001018058 NM_001244583 NM_012252


NM_031198

RefSeq (protein)


NP_001018068.1 NP_001231512.1 NP_036384.1


NP_112475.1

Location (UCSC)

Chr 7: 115.94 – 116.16 Mb

Chr 6: 16.83 – 16.9 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Transcription factor EC is a protein that in humans is encoded by the TFEC gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
↑ "Entrez Gene: TFEC transcription factor EC".

Further reading

Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.". Mol. Cell. Biol. 13 (8): 4505–12. PMC 360062. PMID 8336698.
Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.". Development. 125 (23): 4607–16. PMID 9806910.
Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells.". Biochemistry. 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.". J. Leukoc. Biol. 71 (2): 304–10. PMID 11818452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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