Strictosidine beta-glucosidase
| 3alpha(S)-strictosidine beta-glucosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.105 | ||||||||
| CAS number | 73379-57-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3alpha(S)-strictosidine beta-glucosidase (EC 3.2.1.105) is an enzyme with systematic name strictosidine beta-D-glucohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- strictosidine + H2O D-glucose + strictosidine aglycone
Thus, the two substrates of this enzyme are strictosidine and H2O, whereas its two products are D-glucose and strictosidine aglycone.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. This enzyme participates in indole and ipecac alkaloid biosynthesis.
Strictosidine is a precursor of indole alkaloids.
References
- ↑ Hemscheidt, T.; Zenk, M.H. (1980). "Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures". FEBS Lett. 110: 187–191. doi:10.1016/0014-5793(80)80069-X. PMID 6768587.
- ↑ Luijendijk T.J.C.; Stevens L.H.; Verpoorte R. (1998). "Purification and characterisation of strictosidine beta-D-glucosidase from Catharanthus roseus cell suspension cultures". Plant Physiol. Biochem. 36: 419–425. doi:10.1016/S0981-9428(98)80205-2.
- ↑ Barleben, L.; Ma, X.; Koepke, J.; Peng, G.; Michel, H.; Stöckigt, J. (2005). "Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons". Biochim. Biophys. Acta. 1747: 89–92. doi:10.1016/j.bbapap.2004.09.026. PMID 15680242.
External links
- 3alpha(S)-strictosidine beta-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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