Streptothricin hydrolase

Streptothricin hydrolase (EC 3.5.2.19, sttH (gene)) is an enzyme with systematic name streptothricin-F hydrolase.^[1]^[2] This enzyme catalyses the following chemical reaction

streptothricin-F + H₂O

\rightleftharpoons

streptothricin-F acid

The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid.

References

↑ Maruyama, C.; Hamano, Y. (2009). "The biological function of the bacterial isochorismatase-like hydrolase SttH". Biosci. Biotechnol. Biochem. 73: 2494–2500. doi:10.1271/bbb.90499. PMID 19897889.
↑ Hamano, Y.; Matsuura, N.; Kitamura, M.; Takagi, H. (2006). "A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific". J. Biol. Chem. 281: 16842–16848. doi:10.1074/jbc.m602294200. PMID 16641084.

Streptothricin at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)

3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aspartoacylase Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin

3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase

3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase

3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase

3.5.5: Nitriles/ Aminohydrolases	Nitrilase

3.5.99: Other	Riboflavinase Thiaminase II

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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