Stratum corneum chymotryptic enzyme
| Stratum corneum chymotryptic enzyme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.117 | ||||||||
| CAS number | 155215-90-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Stratum corneum chymotryptic enzyme (EC 3.4.21.117, kallikrein 7, SCCE, KLK7, PRSS6, hK7) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Cleavage of proteins with aromatic side chains in the P1 position
This enzyme has wide substrate specificity.
References
- ↑ Skytt, A., Strömqvist, M. and Egelrud, T. (1995). "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme". Biochem. Biophys. Res. Commun. 211: 586–589. doi:10.1006/bbrc.1995.1853. PMID 7794273.
- ↑ Egelrud, T. (1993). "Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation". J. Invest. Dermatol. 101 (2): 200–204. doi:10.1111/1523-1747.ep12363804. PMID 8393902.
- ↑ Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A. and Egelrud, T. (1994). "Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase". J. Biol. Chem. 269 (30): 19420–19426. PMID 8034709.
- ↑ Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A. and Diamandis, E.P. (2000). "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation". Gene. 254: 119–128. doi:10.1016/S0378-1119(00)00280-8. PMID 10974542.
- ↑ Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J. and Tazi-Ahnini, R. (2004). "Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis". J. Invest. Dermatol. 123: 62–66. doi:10.1111/j.0022-202X.2004.22708.x. PMID 15191543.
External links
- Stratum corneum chymotryptic enzyme at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 1/25/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.