Small nucleolar RNA SNORA73
| Small nucleolar RNA SNORA73 family | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA73 | |
| Identifiers | |
| Symbol | SNORA73 |
| Alt. Symbols | U17 |
| Rfam | RF00045 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000594 |
In molecular biology, the small nucleolar RNA SNORA73 (also called U17/E1 RNA) belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS).[1] This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms.[2]
See also
References
- ↑ Enright, CA; Maxwell ES; Eliceiri GL; Sollner-Webb B (1996). "5'ETS rRNA processing facilitated by four small RNAs: U14, E3, U17, and U3". RNA. 2 (11): 1094–1099. PMC 1369439
. PMID 8903340. - ↑ Cervelli, M; Cecconi F; Giorgi M; Annesi F; Oliverio M; Mariottini P (2002). "Comparative Structure Analysis of Vertebrate U17 Small Nucleolar RNA (snoRNA)". J Mol Evol. 54 (2): 166–179. doi:10.1007/s00239-001-0065-2. PMID 11821910.
External links
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