Sclareol cyclase

Sclareol cyclase
Identifiers
EC number 3.1.7.4
CAS number 146838-18-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Sclareol cyclase (EC 3.1.7.4, geranylgeranyl pyrophosphate:sclareol cyclase, geranylgeranyl pyrophosphate-sclareol cyclase, GGPP:sclareol cyclase) is an enzyme with systematic name geranylgeranyl-diphosphate diphosphohydrolase (sclareol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate + 2 H2O sclareol + diphosphate

This enzyme requires Mg2+ or Mn2+ for activity.

References

  1. Banthorpe, D.V.; Brown, J.T.; Morris, G.S. (1992). "Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material". Phytochemistry. 31 (10): 3391–3395. doi:10.1016/0031-9422(92)83692-R.
  2. Dimas, K.; Hatziantoniou, S.; Tseleni, S.; Khan, H.; Georgopoulos, A.; Alevizopoulos, K.; Wyche, J.H.; Pantazis, P.; Demetzos, C. (2007). "Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice". Apoptosis. 12 (4): 685–694. doi:10.1007/s10495-006-0026-8. PMID 17260186.
  3. Guo, Z.; Wagner, G.J. (1995). "Biosynthesis of labdenediol and sclareol in cell-free extracts from trichomes of Nicotiana glutinosa". Planta. 197 (4): 627–632. doi:10.1007/BF00191570.
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