SNAP91

Identifiers

SNAP91, AP180, CALM, synaptosome associated protein 91kDa, synaptosome associated protein 91

External IDs

MGI: 109132 HomoloGene: 8429 GeneCards: SNAP91

Gene ontology
Molecular function	• clathrin binding • 1-phosphatidylinositol binding • protein binding • phospholipid binding • protein kinase binding
Cellular component	• plasma membrane • clathrin-coated pit • membrane • clathrin-coated vesicle
Biological process	• clathrin coat assembly • protein transport • regulation of clathrin-dependent endocytosis • transport • chemical synaptic transmission
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9892


20616

Ensembl


ENSG00000065609


ENSMUSG00000033419

UniProt


O60641


Q61548

RefSeq (mRNA)

NM_001242792 NM_001242793 NM_001242794 NM_001256717 NM_001256718
NM_014841


NM_001277982 NM_001277983 NM_001277985 NM_001277986 NM_013669

RefSeq (protein)

NP_001229721.1 NP_001229722.1 NP_001229723.1 NP_001243646.1 NP_001243647.1
NP_055656.1


NP_001264911.1 NP_001264915.1 NP_038697.1

Location (UCSC)

Chr 6: 83.55 – 83.71 Mb

Chr 9: 86.77 – 86.88 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the SNAP91 gene.^[3]^[4]^[5]^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ishikawa K; Nagase T; Suyama M; Miyajima N; Tanaka A; Kotani H; Nomura N; Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Yao PJ; O'Herron TM; Coleman PD (Dec 2002). "Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain". Neurobiol Aging. 24 (1): 173–8. doi:10.1016/S0197-4580(02)00055-6. PMID 12493563.
↑ Tebar F; Bohlander SK; Sorkin A (Oct 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol Biol Cell. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. PMC 25500. PMID 10436022.
↑ "Entrez Gene: SNAP91 synaptosomal-associated protein, 91kDa homolog (mouse)".

Murphy JE, Hanover JA, Froehlich M, et al. (1994). "Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain". J. Biol. Chem. 269 (33): 21346–52. PMID 8063760.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Traub LM; Downs MA; Westrich JL; Fremont DH (1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 8907–12. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
Yao PJ; Morsch R; Callahan LM; Coleman PD (1999). "Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry". Neuroscience. 94 (2): 389–94. doi:10.1016/S0306-4522(99)00360-7. PMID 10579202.
Slepnev VI; Ochoa GC; Butler MH; De Camilli P (2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". J. Biol. Chem. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
Han SJ, Lee JH, Hong SH, et al. (2002). "AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity". Biochem. Biophys. Res. Commun. 290 (1): 35–41. doi:10.1006/bbrc.2001.6154. PMID 11779129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scheele U, Alves J, Frank R, et al. (2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". J. Biol. Chem. 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.
Hussain NK, Yamabhai M, Bhakar AL, et al. (2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". J. Biol. Chem. 278 (31): 28823–30. doi:10.1074/jbc.M300995200. PMID 12750376.
Morgan JR, Prasad K, Jin S, et al. (2003). "Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling". J. Biol. Chem. 278 (35): 33583–92. doi:10.1074/jbc.M304346200. PMID 12807910.
Krauss M, Kinuta M, Wenk MR, et al. (2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma". J. Cell Biol. 162 (1): 113–24. doi:10.1083/jcb.200301006. PMC 2172713. PMID 12847086.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhan X; Desiderio DM (2005). "The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry". Biochem. Biophys. Res. Commun. 325 (4): 1180–6. doi:10.1016/j.bbrc.2004.10.169. PMID 15555551.

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SNAP91

References

Further reading