SL2 RNA

SL2 RNA
Predicted secondary structure and sequence conservation of SL2
Identifiers
Symbol SL2
Rfam RF00199
Other data
RNA type Gene
Domain(s) Eukaryota
GO 0000365
SO 0000233

SL2 RNA is a non-coding RNA involved in trans splicing in lower eukaryotes. Trans-splicing is a form of RNA processing. The acquisition of a spliced leader from an SL RNA is an inter-molecular reaction which precisely joins exons derived from separately transcribed RNAs.[1] Approximately 25% of C. elegans genes are organised into polycistronic transcription units and the presence of SL2 on an mRNA is an indication the gene is in an operon.[2]

References

  1. Dassanayake, RS; Chandrasekharan NV; Karunanayake EH (2001). "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria bancrofti, and a sensitive polymerase chain reaction based detection assay". Gene. 269 (1-2): 185193. doi:10.1016/S0378-1119(01)00438-3. PMID 11376950.
  2. Evans, D; Blumenthal T (2000). "trans splicing of polycistronic Caenorhabditis elegans pre-mRNAs: analysis of the SL2 RNA". Mol Cell Biol. 20 (18): 66596667. doi:10.1128/MCB.20.18.6659-6667.2000. PMC 86170Freely accessible. PMID 10958663.

External links

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