Rhizopuspepsin
| Rhizopuspepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.21 | ||||||||
| CAS number | 2620497 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Rhizopuspepsin (EC 3.4.23.21, Rhizopus aspartic proteinase, neurase, Rhizopus acid protease, Rhizopus acid proteinase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen.
From the zygomycete fungus Rhizopus chinensis. A similar endopeptidase is found in R. niveus [2]. In peptidase family A1 (pepsin A family).
References
- ↑ Tsuru, D.; Hattori, A.; Tsuji, H.; Yamamoto, T.; Fukumoto, J. (1969). "Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis". Agric. Biol. Chem. 33: 1419–1426. doi:10.1080/00021369.1969.10859482.
- ↑ Kurono, Y.; Chidimatsu, M.; Horikoshi, K.; Ikeda, Y. (1971). "Isolation of a protease from a Rhizopus product". Agric. Biol. Chem. 35: 1668–1675. doi:10.1271/bbb1961.35.1668.
- ↑ Ohtsuru, M.; Tang, J.; Delaney, R. (1982). "Purification and characterization of rhizopuspesin isozymes from a liquid culture of Rhizopus chinensis". Int. J. Biochem. 14 (10): 925–932. doi:10.1016/0020-711x(82)90077-5. PMID 6751894.
- ↑ Suguna, K.; Padlan, E.A.; Smith, C.W.; Carlson, W.D.; Davies, D.R. (1987). "Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action". Proc. Natl. Acad. Sci. USA. 84: 7009–7013. doi:10.1073/pnas.84.20.7009. PMC 299218
. PMID 3313384.
External links
- Rhizopuspepsin at the US National Library of Medicine Medical Subject Headings (MeSH)
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