Rhamnulose-1-phosphate aldolase
| rhamnulose-1-phosphate aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.2.19 | ||||||||
| CAS number | 9054-58-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a rhamnulose-1-phosphate aldolase (EC 4.1.2.19) is an enzyme that catalyzes the chemical reaction
- L-rhamnulose 1-phosphate glycerone phosphate + (S)-lactaldehyde
Hence, this enzyme has one substrate, L-rhamnulose 1-phosphate, and two products, glycerone phosphate and (S)-lactaldehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-rhamnulose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include rhamnulose phosphate aldolase, L-rhamnulose 1-phosphate aldolase, L-rhamnulose-phosphate aldolase, and L-rhamnulose-1-phosphate lactaldehyde-lyase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1GT7 and 1OJR.
References
- Chiu TH, Feingold DS (1969). "L-rhamnulose 1-phosphate aldolase from Escherichia coli Crystallization and properties". Biochemistry. 8 (1): 98–108. doi:10.1021/bi00829a015. PMID 4975916.
- Sawada H; Takagi Y (1964). "The metabolism of L-rhamnose in Escherichia coli. 3 L-Rhamulose-phosphate aldolase". Biochim. Biophys. Acta. 92: 26–32. doi:10.1016/0926-6569(64)90265-2. PMID 14243785.