Polynucleotide 3'-phosphatase

polynucleotide 3'-phosphatase
Identifiers
EC number 3.1.3.32
CAS number 37288-16-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a polynucleotide 3'-phosphatase (EC 3.1.3.32) is an enzyme that catalyzes the chemical reaction

a 3'-phosphopolynucleotide + H2O a polynucleotide + phosphate

Thus, the two substrates of this enzyme are 3'-phosphopolynucleotide and H2O, whereas its two products are polynucleotide and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is polynucleotide 3'-phosphohydrolase. Other names in common use include 2'(3')-polynucleotidase, DNA 3'-phosphatase, deoxyribonucleate 3'-phosphatase, and 5'-polynucleotidekinase 3'-phosphatase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1UJX and 2BRF.

References


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